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An anonymous reader shares a report: More than 2% of Americans are taking the blockbuster class of GLP-1 drugs for overweight or obesity, up nearly 600% over six years, according to a report from FAIR Health given to Axios first. The data from FAIR Health's repository of over 51 billion commercial healthcare claim records shows the explosion in use of the drugs specifically for weight loss -- roughly half of all users. In all, roughly 4% of Americans were taking GLP-1 drugs in 2024 for either overweight, obesity or Type 2 diabetes (their original approved use). The data shows Novo Nordisk's Ozempic is still by far the most commonly taken GLP-1, followed by Eli Lilly's Mounjaro. The percentage of adults who were prescribed a GLP-1 drug but did not have bariatric surgery increased from 2.5% in 2019 to 11.2% in 2024 while the the percentage of adult patients who had bariatric surgery decreased 41.8%.

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He'll need to be way more aggressive than a 25% tariff, say analysts, and even then it would take years

US President Donald Trump can huff, puff, and threaten to blow Tim Cook's house down with a 25 percent iPhone import tariff, but analysts say even that threat is unlikely to bring Apple's manufacturing home.…

Researchers are developing techniques to genetically modify cancer-fighting immune cells directly inside patients rather than in expensive laboratory facilities, potentially making CAR-T therapy accessible to far more people. Current CAR-T treatments require removing a patient's T cells, shipping them to specialized facilities for genetic engineering, then returning them weeks later at costs around $500,000 per dose. The new "in vivo" approaches use viral vectors or RNA-loaded nanoparticles to deliver genetic instructions directly to T cells circulating in the bloodstream, which could reduce costs by an order of magnitude. Companies including Capstan Therapeutics, co-founded by Nobel laureates, and AstraZeneca-backed EsoBiotec have launched early human trials. While only about 200 US centers currently offer traditional CAR-T therapy, the approach could make the powerful treatment available on demand like conventional drugs.

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Nick Clegg, former politico and Zuckcorp policy Prez, seems confused, can Reg readers help him?

Former British deputy PM and Meta apologist Sir Nick Clegg says that forcing AI companies to ask for the permission of copyright holders before using their content would destroy the AI industry overnight.…

German sportswear giant Adidas disclosed a data breach after attackers hacked a customer service provider and stole some customers' data. From a report: "adidas recently became aware that an unauthorized external party obtained certain consumer data through a third-party customer service provider," the company said. "We immediately took steps to contain the incident and launched a comprehensive investigation, collaborating with leading information security experts." Adidas added that the stolen information did not include the affected customers' payment-related information or passwords, as the threat actors behind the breach only gained access to contact. The company has also notified the relevant authorities regarding this security incident and will alert those affected by the data breach.

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More than 50 years after its debut, Uno has achieved unprecedented popularity among adults, but its resurgence is creating problems and confusions as players disagree on fundamental rules. WSJ, in a fun story [non-paywalled source]: Think politics divides? Try mixing competitors with different views on stacking "action" cards, or getting everyone to agree on the true power of the Wild card. And nobody can seem to decide whether staples of the game of their youth -- like mandating players yell "Uno!" when they have one card left -- are socially acceptable at a bar with strangers. Mattel has responded by actively settling rule debates on social media, definitively stating that stacking Draw 2 cards is prohibited, while simultaneously embracing the game's divisive nature through marketing campaigns. The company's "Show 'Em No Mercy" variant, featuring more aggressive rules, became the second-best-selling card game in the United States last year according to research firm Circana, trailing only classic Uno itself.

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Hackers take personal data bytes from the brand with three stripes

Adidas is warning customers some of their data was stolen after an "unauthorized" person lifted it from a "third-party customer service provider."…

The Browser Company has ceased the active development of its Arc browser to focus on Dia, a new AI-powered browser currently in alpha testing, the company said Tuesday. In a lengthy letter to users, CEO Josh Miller said the startup should have stopped working on Arc "a year earlier," noting data showing the browser suffered from a "novelty tax" problem where users found it too different to adopt widely. Arc struggled with low feature adoption -- only 5.52% of daily active users regularly used multiple Spaces, while 4.17% used Live Folders. The company will continue maintenance updates for Arc but won't add new features. Arc also won't open-source the browser because it relies on proprietary infrastructure called ADK (Arc Development Kit) that remains core to the company's value.

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Marc Benioff eyes up all those lovely data tools for AI push

Salesforce is to buy Informatica, the enterprise data management and analytics biz, for around $8 billion.…

Commercial customers, STEM students all feeling the pain after mega outage of engineering data-analysis tool

Software biz MathWorks is cleaning up a ransomware attack more than a week after it took down MATLAB, its flagship product used by more than five million people worldwide.…

President Trump's threat of a 25% tariff on smartphone imports including iPhones would not provide enough economic incentive for Apple to relocate US-bound iPhone production to domestic facilities, according to a new Morgan Stanley note viewed by Slashdot. The tariff threat, announced Friday via social media, appeared to target Apple's recent shift of iPhone production from China to India through its contract manufacturing partners. Morgan Stanley analysts estimate that establishing US iPhone production would require a minimum of two years and several billion dollars to build multiple greenfield assembly facilities, with a trained workforce exceeding 100,000 workers during peak seasons. More significantly, the firm calculates that a US-produced iPhone would cost 35% more than current China or India production, primarily due to higher labor costs and the need to import 25% of iPhone components from China under existing 30% tariffs. By contrast, Apple could offset a 25% import tariff by raising global iPhone prices just 4-6%, making domestic production economically unviable.

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Taxpayers on hold for 798 years might wish for a better service

The UK's tax collector has confirmed plans to contract out call center services with an associated price tag of £500 million ($677 million).…

Prediction: General-purpose AI could start getting worse

Opinion I use AI a lot, but not to write stories. I use AI for search. When it comes to search, AI, especially Perplexity, is simply better than Google.…

Abstract of a paper on NBER: We elicited over a million stated preference choices over 126 dimensions or "aspects" of well-being from a sample of 3,358 respondents on Amazon's Mechanical Turk (MTurk). Our surveys also collected self-reported well-being (SWB) questions about respondents' current levels of the aspects of well-being. From the stated preference data, we estimate relative log marginal utilities per point on our 0-100 response scale for each aspect. We validate these estimates by comparing them to alternative methods for estimating preferences. Our findings provide empirical evidence that both complements and challenges philosophical perspectives on human desires and values. Our results support Aristotelian notions of eudaimonia through family relationships and Maslow's emphasis on basic security needs, yet also suggest that contemporary theories of well-being may overemphasize abstract concepts such as happiness and life satisfaction, while undervaluing concrete aspects such as family well-being, financial security, and health, that respondents place the highest marginal utilities on. We document substantial heterogeneity in preferences across respondents within (but not between) demographic groups, with current SWB levels explaining a significant portion of the variation.

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Or, rediscovering the KISS principle, the long way round

Comment Linux distro wars are nothing new. "Advocacy" (a euphemism for angry argument) about hardware, OSes, programming languages and editors goes back as long as different computers have existed. Computers appeal to geeky folks, and geeky folks readily get a little too attached to things — and then become possessive and defensive about them.…

Nothing will change while big tech sets the rules. We'll need someone even scarier

Opinion How much harm does AI cause the environment? As a report from the MIT Technology Review just confirmed, nobody knows, and almost nobody cares enough to try and find out. Even if lots of people did care a lot, it wouldn’t change things. The driver of AI’s insane energy addiction is no more amenable to argument than a labrador in possession of an entire roast chicken.…

The European Commission warned Chinese e-tailer SHEIN on Monday that it must address multiple consumer law violations or face fines across EU member states. Regulators found SHEIN's website displayed fake discounts not based on actual prior prices, used pressure-selling tactics with false purchase deadlines, provided misleading information about consumer return rights, made deceptive sustainability claims, and hid contact details from customers. SHEIN has one month to respond to the findings and propose corrective measures, adding regulatory pressure to a company already facing US tariff challenges despite generating an estimated $38 billion in revenue last year.

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No, not Amazon. China’s SHEIN is in the spotlight for fake discounts, grubby greenery, and evading inquiries

The European Commission has warned Chinese e-tailer SHEIN to clean up its act, after finding several practices on its website breach local consumer law.…

California's population grew 0.6% in 2024, adding nearly 250,000 residents to reach 39.43 million, according to Census Bureau estimates. The growth came entirely from a rebound in international immigration, which surged to over 300,000 people after plunging to 44,000 during the pandemic's worst year. Without immigration, the state would have shrunk significantly as domestic migration remained negative. The H-1B visa program alone brought nearly 79,000 skilled workers to California in 2024. Since 2010, California has added 2.7 million immigrants, with half coming from Asia and slightly more than a third from Latin America. The immigration-dependent growth model puts California at particular risk from potential federal policy changes, as more than a quarter of its population is foreign-born -- the highest share nationwide.

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Taiwan's tech expo dishes up the usual oddities - some less bonkers than they seem

Computex Taiwan’s Computex conference sprawls across four exhibition halls in which almost 1,500 exhibitors jostle for attention.…