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Researchers are developing techniques to genetically modify cancer-fighting immune cells directly inside patients rather than in expensive laboratory facilities, potentially making CAR-T therapy accessible to far more people. Current CAR-T treatments require removing a patient's T cells, shipping them to specialized facilities for genetic engineering, then returning them weeks later at costs around $500,000 per dose. The new "in vivo" approaches use viral vectors or RNA-loaded nanoparticles to deliver genetic instructions directly to T cells circulating in the bloodstream, which could reduce costs by an order of magnitude. Companies including Capstan Therapeutics, co-founded by Nobel laureates, and AstraZeneca-backed EsoBiotec have launched early human trials. While only about 200 US centers currently offer traditional CAR-T therapy, the approach could make the powerful treatment available on demand like conventional drugs.

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Nick Clegg, former politico and Zuckcorp policy Prez, seems confused, can Reg readers help him?

Former British deputy PM and Meta apologist Sir Nick Clegg says that forcing AI companies to ask for the permission of copyright holders before using their content would destroy the AI industry overnight.…

German sportswear giant Adidas disclosed a data breach after attackers hacked a customer service provider and stole some customers' data. From a report: "adidas recently became aware that an unauthorized external party obtained certain consumer data through a third-party customer service provider," the company said. "We immediately took steps to contain the incident and launched a comprehensive investigation, collaborating with leading information security experts." Adidas added that the stolen information did not include the affected customers' payment-related information or passwords, as the threat actors behind the breach only gained access to contact. The company has also notified the relevant authorities regarding this security incident and will alert those affected by the data breach.

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More than 50 years after its debut, Uno has achieved unprecedented popularity among adults, but its resurgence is creating problems and confusions as players disagree on fundamental rules. WSJ, in a fun story [non-paywalled source]: Think politics divides? Try mixing competitors with different views on stacking "action" cards, or getting everyone to agree on the true power of the Wild card. And nobody can seem to decide whether staples of the game of their youth -- like mandating players yell "Uno!" when they have one card left -- are socially acceptable at a bar with strangers. Mattel has responded by actively settling rule debates on social media, definitively stating that stacking Draw 2 cards is prohibited, while simultaneously embracing the game's divisive nature through marketing campaigns. The company's "Show 'Em No Mercy" variant, featuring more aggressive rules, became the second-best-selling card game in the United States last year according to research firm Circana, trailing only classic Uno itself.

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Hackers take personal data bytes from the brand with three stripes

Adidas is warning customers some of their data was stolen after an "unauthorized" person lifted it from a "third-party customer service provider."…

The Browser Company has ceased the active development of its Arc browser to focus on Dia, a new AI-powered browser currently in alpha testing, the company said Tuesday. In a lengthy letter to users, CEO Josh Miller said the startup should have stopped working on Arc "a year earlier," noting data showing the browser suffered from a "novelty tax" problem where users found it too different to adopt widely. Arc struggled with low feature adoption -- only 5.52% of daily active users regularly used multiple Spaces, while 4.17% used Live Folders. The company will continue maintenance updates for Arc but won't add new features. Arc also won't open-source the browser because it relies on proprietary infrastructure called ADK (Arc Development Kit) that remains core to the company's value.

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Marc Benioff eyes up all those lovely data tools for AI push

Salesforce is to buy Informatica, the enterprise data management and analytics biz, for around $8 billion.…