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Scientists at Melbourne's Peter Doherty Institute for Infection and Immunity are working on a Crispr-based treatment -- delivered as a nasal spray or injection -- that could stop influenza infections by targeting the virus's RNA and disrupting its ability to replicate inside human cells. The approach uses the Cas13 enzyme, a lesser-known cousin of the DNA-cutting Cas9, which can be engineered to seek out conserved regions of influenza's genetic code that are found in virtually all flu strains and are crucial to the virus's survival. The delivery mechanism would use lipid nanoparticles to ferry two molecular instructions to flu-infected cells in the respiratory tract: an mRNA that tells cells to produce Cas13 and a guide RNA that directs the enzyme to specific parts of the influenza virus's code. Cas13 then cuts the viral RNA and effectively stops the infection at the genetic level, Sharon Lewin, the infectious diseases physician leading the project, told Wired. Early safety testing at Harvard's Wyss Institute used a "lung on a chip" model to examine whether human cells producing Cas13 could fight off flu strains including H1N1 and H3N2. The institute's founding director Donald Ingber says the studies showed no off-target effects.

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Public opinion surveys paint a picture of Americans souring dramatically on higher education, as Pew found that the share of adults calling college "very important" dropped from 70% in 2013 to just 35% today, and NBC polling shows that 63% now believe a degree is "not worth the cost," up from 40% over the same period. Yet enrollment data tells a different story. Four-year institutions awarded 2 million bachelor's degrees in 2023, up from 1.6 million in 2010, and the fraction of 25-year-olds holding a bachelor's degree has steadily increased for the past 15 years. The economic case remains strong. The average bachelor's degree holder earns about 70% more than a high-school graduate of similar work experience, and after factoring in financial aid, the cost of attending a public four-year college has fallen by more than 20% since 2015. Even after accounting for student-debt payments, college graduates net about $8,000 more annually than those without degrees. Part of the disconnect may stem from misunderstanding how college pricing works. Nearly half of U.S. adults believe everyone pays the same tuition, though fewer than 20% of families actually pay the published sticker price.

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