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Tens of thousands of people have fallen victim to predatory loan apps, which extort users using sensitive information from their phones. Google has changed its policy to prevent the loan apps from being listed on the Play store, but enforcement is unreliable. Rest of World: According to Mexico City's Citizen Council for Safety and Justice, a consumer watchdog group, 135 reports to local authorities have been filed against JoyCredito for fraud and extortion. But despite the government attention, the app is still available to download from the Google Play store. For years, apps like JoyCredito have been exploiting borrowers from Mexico to India. They lend small amounts of money with few requirements and very high interest rates to financially vulnerable people -- and then extort them when the loan is due. After years of mounting pressure from watchdog groups, Google explicitly banned the apps from the Play store in October. But stories like those of Macias Gonzalez show how widespread the apps still are -- and how ineffective Google has been at enforcing its own policy. Rest of World presented Google with 15 instances of exploitative loan apps based in Mexico that explicitly violate the terms of the Play store. All of them were still available in the store as of press time. Of the 15 apps, 12 explicitly asked for access to either the camera roll or contacts in the Google Play store's terms of services. Two others specified full access only in external documents. One other gave no data access information. Rest of World also found 10 apps in Peru that have been flagged as exploitative by SBS, a national body that oversees banking, insurance, and private pension. All the apps are still available for download on the Google Play store.

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Terraform Labs, the company behind the stablecoin TerraUSD, which collapsed and roiled cryptocurrency markets in 2022, filed for Chapter 11 bankruptcy in the United States, according to court papers filed on Sunday. From a report: Singapore-based Terraform Labs, in a filing with the bankruptcy court in Delaware, listed assets and liabilities in the range of $100-$500 million. Terraform Labs said it would meet all financial obligations to employees and vendors during the Chapter 11 case without requiring additional financing. It also plans to continue Web3 offerings expansion. "The filing will allow TFL to execute on its business plan while navigating ongoing legal proceedings, including representative litigation pending in Singapore and U.S. litigation involving the Securities and Exchange Commission (SEC)," Terraform Labs said in a statement.

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theodp writes: OpenAI has banned the developer of a bot that mimicked Democratic White House hopeful Rep. Dean Phillips, the first known instance where the maker of ChatGPT has restricted the use of AI in political campaigns. OpenAI suspended the account of the start-up Delphi, which had been contracted to build Dean.Bot, which could talk to voters in real-time via a website. "Anyone who builds with our tools must follow our usage policies," a spokesperson for OpenAI said in a statement shared with Axios on Sunday. "We recently removed a developer account that was knowingly violating our API usage policies which disallow political campaigning, or impersonating an individual without consent." OpenAI apparently is not a fan of Richard Stallman's 'freedom 0' tenet, which argues software users should have the freedom to run programs as they wish, in order to do what they wish (Stallman is careful to note this freedom doesn't make one exempt from laws). The suspension and subsequent bot removal occurred ahead of Tuesday's New Hampshire primary, where Phillips continues his long-shot presidential bid against President Biden.

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The U.S. Federal Aviation Administration is recommending that airlines check a second type of Boeing jet that uses the same kind of door plug as the one that blew out of an Alaska Airlines flight earlier this month. From a report: The FAA said late Sunday that it advises operators of Boeing's 737-900ER aircraft to inspect the planes' midexit door plugs. The recommendation comes weeks after the midair accident involving a 737 MAX 9 jet. The 900ER jet isn't part of Boeing's newer MAX family of aircraft, but its door-plug design is identical to the MAX 9's, the FAA said in a release. The FAA cited "an added layer of safety" in recommending the inspections and called for visual checks of four places where door plugs are secured to airplanes. It said some operators had already checked 900ER door plugs and "noted findings with bolts." In a statement, Boeing said, "We fully support the FAA and our customers in this action." The agency grounded 171 MAX 9 airplanes after the Alaska Airlines midair accident and emergency landing on Jan. 5. The grounding remains in place pending a review and approval of inspection and maintenance processes. Boeing has delivered 505 of its 900ER aircraft globally to airlines including Alaska Airlines, United Airlines, Delta Air Lines and Indonesia's Lion Air, according to company data.

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It's the 50th anniversary of Devo, the geek-friendly, dystopia-themed band that combined synthesizers with showmanship, first founded in 1973. As a new documentary about the group celebrates its Sundance world premiere, the Los Angeles Times explores how the band made innovative use of the technology of its time: With their yellow radiation suits, red "energy dome" hats and manic energy, part playful and part angry, the band Devo combined the futuristic glamour of new wave with atomic-age anxieties and post-'60s disillusionment.... Uniquely, the band developed a fully formed, intricate internal philosophy and mythology built around the idea that humans were "de-evolving" by becoming dumber and less sophisticated. The mascot of the band, known as "Booji Boy," was an infantile urchin in a rubber mask... Was there an idea to document the band right from the very start? It's incredible that there's footage of the very first show in 1973. GERALD CASALE: We were that delusional, yes. And we were trying to document ourselves when nobody was interested in doing that. And when it was quite expensive and clumsy to do it. You're dealing with Sony U-matic reel-to-reel recorders and big heavy cameras and a scarcity of equipment and very little interest. I mean, my God, if a Devo of now existed like we did, then clearly, there'd be a million cellphone videos. MARK MOTHERSBAUGH: [...] Bob was the first of us to direct a video, back when he was in high school. Bob and me, our dad, starting when we were like babies, like 1 year old, he'd bring out an 8-millimeter camera that didn't have sound, and so he shot hundreds and hundreds of these films through the years, just family stuff. So we always kind of liked that. And Jerry was doing films at Kent State with Chuck Statler before Chuck said, "Hey, let's do a film with a couple of the songs in it." So we were always audio-visual. We were always thinking in both worlds... [DOCUMENTARY DIRECTOR] CHRIS SMITH: One of my favorite details in looking through the old footage is, there's an early show that was recorded in black-and-white, and they have such limited materials to work with, yet they do this thing where the light goes on and off on both sides of the stage. And to me it was so emblematic of where they were going because they were making something that you hadn't seen before that was super creative and visually distinctive and interesting out of something we all had to work with... You could see in that footage, the inventiveness that wasn't a result of means — it was something that was just created out of what they had to work with at that time. MARK MOTHERSBAUGH: [...] Sonically, a lot of what we did was just related to the fact that Bob Mothersbaugh bought a four-track TEAC. So we had this machine that could record four little skinny channels on a quarter-inch tape. It was an amateur home-tape machine, but it made us think about our parts, because we thought, well, OK, you're only going to get to do the bass on one track, and the guitar on one track and the drums on one track and the synth. You're not going to do all these overdubs. We had to think about it, what was an essential part. So we'd work on the song till you could play it just in one pass. Everything essential. I think it really made the early stuff sound really strong because of that. You really get a sense of that on their 1978 song "Mongoloid." But the 2023 documentary's director doesn't see his film as an ending bookmark for the band. "They're still touring. They're all still actively creatively pursuing many different things, as I hope that you would expect after seeing the film." And speaking specifically about the documentary. Mark Mothersbaugh says Booji Boy "describes it as a halfway point to the year of 2073, where we'll celebrate the 100-year anniversary." Booji Boy also says the next 50 years will be more about action. "And it'll be about positive mutation. Mutate, don't stagnate."

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The Seattle Times reports: Concerns have grown in recent weeks about data privacy and the ongoing impacts of a recent Fred Hutchinson Cancer Center cyberattack that leaked personal information of about 1 million patients last November. Since the breach, which hit the South Lake Union cancer research center's clinical network and has led to a host of email threats from hackers and lawsuits against Fred Hutch, menacing messages from perpetrators have escalated. Some patients have started to receive "swatting" threats, in addition to spam emails warning people that unless they pay a fee, their names, Social Security and phone numbers, medical history, lab results and insurance history will be sold to data brokers and on black markets. Steve Bernd, a spokesperson for FBI Seattle, said last week there's been no indication of any criminal swatting events... Other patients have been inundated with spam emails since the breach... According to The New York Times, large data breaches like this are becoming more common. In the first 10 months of 2023, more than 88 million individuals had their medical data exposed, according to the Department of Health and Human Services. Meanwhile, the number of reported ransomware incidents, when a specific malware blocks a victim's personal data until a ransom is paid, has decreased in recent years — from 516 in 2021 to 423 in 2023, according to Bernd of FBI Seattle. In Washington, the number dropped from 84 to 54 in the past three years, according to FBI data. Fred Hutchinson Cancer Center believes their breach was perpetrated outside the U.S. by exploiting the "Citrix Bleed" vulnerability (which federal cybersecurity officials warn can allow the bypassing of passwords and mutifactor authentication measures). The article adds that in late November, the Department of Health and Human Services' Health Sector Cybersecurity Coordination Center "urged hospitals and other organizations that used Citrix to take immediate action to patch network systems in order to protect against potentially significant ransomware threats."

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"Bell Labs, the historic headwaters of so many inventions that now define our digital age, is closing in Murray Hill," writes journalism professor Jeff Jarvis (in an op-ed for New Jersey's Star-Ledger newspaper). "The Labs should be preserved as a historic site and more." I propose that Bell Labs be opened to the public as a museum and school of the internet. The internet would not be possible without the technologies forged at Bell Labs: the transistor, the laser, information theory, Unix, communications satellites, fiber optics, advances in chip design, cellular phones, compression, microphones, talkies, the first digital art, and artificial intelligence — not to mention, of course, many advances in networks and the telephone, including the precursor to the device we all carry and communicate with today: the Picturephone, displayed as a futuristic fantasy at the 1964 World's Fair. There is no museum of the internet. Silicon Valley has its Computer History Museum. New York has museums for television and the moving image. Massachusetts boasts a charming Museum of Printing. Search Google for a museum of the internet and you'll find amusing digital artifacts, but nowhere to immerse oneself in and study this immensely impactful institution in society. Where better to house a museum devoted to the internet than New Jersey, home not only of Bell Labs but also at one time the headquarters of the communications empire, AT&T, our Ma Bell...? The old Bell Labs could be more than a museum, preserving and explaining the advances that led to the internet. It could be a school... Imagine if Bell Labs were a place where scholars and students in many disciplines — technologies, yes, but also anthropology, sociology, psychology, history, ethics, economics, community studies, design — could gather to teach and learn, discuss and research. The text of Jarvis's piece is behind subscription walls, but has apparently been re-published on X by innovation theorist John Nosta. In one of the most interesting passages, Jarvis remembers visiting Bell Labs in 1995. "The halls were haunted with genius: lab after lab with benches and blackboards and history within. We must not lose that history."

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One man living in Virginia oversaw "the laundering of some $7 million in fraudulently obtained gift cards" from Walmart in an international operation which over five years scammed hundreds of victims into sending the numbers over the phone, reports a new ProPublica investigation. (Citing court evidence that emerged after his arrested in 2021). Earlier that year, he complained to an associate that more and more people were competing to resell cards in China, eating into his profits. So many scammers were flocking to Walmart that he and his team regularly encountered them at self-checkout counters.... "We ran into quite a few at the store, and we even started chatting." It was apparently so common that federal prosecutors started calling it "The Walmart scheme." And while the store is supposed to watch for customers who appear to be acting on a scammer's instructions, "Too often, Walmart has failed." America's largest retailer has long been a facilitator of fraud on a mass scale, a ProPublica investigation has found. For roughly a decade, Walmart has resisted tougher enforcement while breaking promises to regulators and skimping on employee training, according to more than 50 interviews, internal documents supplied by former industry executives, court filings and other public records...More than $1 billion in fraud losses were routed through the company's financial systems between 2013 and 2022, according to filings by the Federal Trade Commission and court cases analyzed by ProPublica. That has helped fuel a boom in financial chicanery. Americans, many of them elderly, were swindled out of $27 billion between 2013 and 2022, according to the FTC... Walmart has a financial incentive to avoid cracking down. It makes money each time a Walmart gift card is used and earns a fee when another brand of card is bought. And it receives one commission when a person sends a money transfer and a second when the recipient picks it up. The company's financial services business generates hundreds of millions in annual profits. (Its filings do not provide specific figures for gift cards and money transfers.) "They were concerned about the bucks. That's all," Nick Alicea, a former fraud team leader for the U.S. Postal Inspection Service who investigated Walmart for years, told ProPublica. Walmart's deficiencies have repeatedly attracted government scrutiny. In 2017, the attorneys general of New York and Pennsylvania investigated Walmart over concerns that it was "reaping the benefits" of gift card fraud. The investigation concluded a year later with Walmart promising to restrict or eliminate the use of its gift cards to purchase other gift cards... Instead, the company let the practice continue until 2022 — even after it knew that millions of dollars were being laundered through its stores. The FTC sued Walmart in 2022, alleging it "turned a blind eye" as criminals took advantage of its money transfer service. Walmart, the FTC claimed, pocketed millions in fees while "letting fraudsters fleece its customers." Summarizing the FTC's evidence, a federal judge in the case wrote that "Walmart knew that its services were used by fraudsters" and that the company was repeatedly warned about certain stores where "twenty-five, fifty, or even seventy-five percent of money transfer activity was fraudulent." Separately, a federal grand jury in Pennsylvania is hearing evidence of possible criminal conduct in Walmart's money transfer business, according to corporate filings that did not detail the allegations. While the FTC says Americans were swindled out of $27 billion between 2013 and 2022, Walmart responded to ProPublica's investigation by pointing out it's refunded $4 million to gift-card fraud victims, and also blocked more than $700 million in suspicious money transfers. "We have a robust anti-fraud program and other controls to help stop scammers and other criminals who may use the financial services we offer to harm our customers." The company's legal filings in the FTC case struck a different tone. Walmart is seeking to dismiss the suit, partly on the grounds that it has "no responsibility to protect against the criminal conduct of third parties." Though fraud is "deeply unfortunate," Walmart argues, such schemes are "reasonably avoidable by consumers." Other interesting quotes from the article: "Walmart outlets at one point accounted for the top 20 locations for fraud nationally among chains that partnered with MoneyGram, according to internal documents." "In a single week in March 2017, consumers claiming they'd been duped into a money transfer filed 610 complaints about Walmart, according to documents obtained by ProPublica. CVS ranked second, with 47." "Site inspections routinely found that Walmart staff lacked anti-fraud training and that employees failed to ask screening questions..." Walmart resisted MoneyGram's attempts to fight fraud [according to the former fraud team leader for the postal inspector's office in Harrisburg, Pennsylvania, who investigated MoneyGram and Walmart].

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The pandemic may have proved to employeers that remote and flexible-work arrangements were viable — and changed the way we work forever. Axios writes: Just 6 out of 158 U.S. CEOs said they'll prioritize bringing workers back to the office full-time in 2024, according to a new survey released by the Conference Board. Executives are increasingly resigned to a world where employees don't come in every day, as hybrid work arrangements — mixing work from home and in-office — become the norm for knowledge workers. "Maintain hybrid work," was cited as a priority by 27% of the U.S. CEOs who responded to the survey, conducted in October and November. A separate survey of chief financial officers by Deloitte, conducted in November, found that 65% of CFOs expect their company to offer a hybrid arrangement this year. "Remote work appears likely to be the most persistent economic legacy of the pandemic," write Goldman Sachs economists in a recent note. About 20%-25% of workers in the U.S. work from home at least part of the week, according to data Goldman cites. That's below a peak of 47% during the pandemic but well above its prior average of around 3%. "The battle is over," said Diana Scott, human capital center leader at The Conference Board. "There are so many other issues CEOs are facing." Headlines about CEOs determined to get butts in seats get attention, but they are the exception, says Brian Elliott, the cofounder of Future Forum, a future of work think tank. "There are a lot more CEOs that are actually quietly becoming more flexible...." Though the labor market has softened, employers still do care about keeping employees satisfied — and they don't want to fight with them. "It's not worth the fight," says Elliott.

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The pandemic may have proved to employeers that remote and flexible-work arrangements were viable — and changed the way we work forever. Axios writes: Just 6 out of 158 U.S. CEOs said they'll prioritize bringing workers back to the office full-time in 2024, according to a new survey released by the Conference Board. Executives are increasingly resigned to a world where employees don't come in every day, as hybrid work arrangements — mixing work from home and in-office — become the norm for knowledge workers. "Maintain hybrid work," was cited as a priority by 27% of the U.S. CEOs who responded to the survey, conducted in October and November. A separate survey of chief financial officers by Deloitte, conducted in November, found that 65% of CFOs expect their company to offer a hybrid arrangement this year. "Remote work appears likely to be the most persistent economic legacy of the pandemic," write Goldman Sachs economists in a recent note. About 20%-25% of workers in the U.S. work from home at least part of the week, according to data Goldman cites. That's below a peak of 47% during the pandemic but well above its prior average of around 3%. "The battle is over," said Diana Scott, human capital center leader at The Conference Board. "There are so many other issues CEOs are facing." Headlines about CEOs determined to get butts in seats get attention, but they are the exception, says Brian Elliott, the cofounder of Future Forum, a future of work think tank. "There are a lot more CEOs that are actually quietly becoming more flexible...." Though the labor market has softened, employers still do care about keeping employees satisfied — and they don't want to fight with them. "It's not worth the fight," says Elliott.

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The Wall Street Journal reports: Moves by Broadcom to shore up its $69 billion VMware acquisition, completed in November, include a streamlining of product bundles and new billing models — efforts in line with the chip giant's past acquisitions, but not necessarily welcomed by all of VMware's customers... Broadcom has also recently laid off at least hundreds of VMware workers, disclosures from the Worker Adjustment and Retraining Notification show.... VMware has approximately 330,000 customers, according to the company. Chief information officers say they are closely monitoring what comes next. "Any CIO that's not taking stock of what they have and mentally considering alternatives and monitoring what else is out there is probably not doing their job," said Jay Ferro, executive vice president and chief information, technology and product officer at clinical research data-management company Clario. All these changes, plus past remarks by Broadcom that its go-to-market strategy is to focus completely on the needs and priorities of its top 600 customers, has left some CIOs rethinking the relationship. Price increases and degrading levels of support are among their biggest concerns. "I'm not one of their top, probably 600 customers, so they've been very clear to me where I fit in that pecking order," said Todd Florence, CIO of trucking company Estes Express Lines. Florence said he's started looking into alternatives. "It certainly doesn't make you feel good, like you're going to get lots of support going forward...." Goya Foods CIO Suvajit Basu said he is thinking about how to reduce the food company's reliance on VMware as the sole and longtime dominant provider of virtualization for the data center. "They're going to increase their prices or change their licensing so the customer pays more," he said. "And I think this is starting to hit us right now...." Forrester estimates that in 2024, 20% of VMware customers will begin the process of exiting VMware in favor of alternatives. On the other hand, a group VP at market researcher IDC tells the Journal that on the upside, now VMware and Broadcom will have to engage more actively with customers on the value of new produces included in their bundles...

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Slashdot reader quonset writes: After decades of study and testing, a potential vaccine for cancer may be on the horizon. Dr. Thomas Wagner, founder of Orbis Health Solutions, is using the body's own immune system to fight the disease, with each shot personalized to the patient, according to ABC News. From the article: Typically, cancer cells evade a person's immune system because it is recognized as that person's cells. Wagner developed a tumor lysate particle only (TLPO) vaccine that uses a person's tumor cells to identify particular parts that are then presented back in the body using the vaccine in a way that can stimulate their immune system to gain the ability to detect these cancer cells like an infection, allowing the immune system to fight the cancer itself. "People used to ask me the question, 'When will there be a cure for cancer?' And I've been doing this for 60 years and I could never answer that question," Wagner said. "Until recently, until the last three or four or five years." Wagner believes this type of cancer treatment could be a key to finding the long-awaited cure for cancer, all cancers, if paired with early detection. Wagner's TLPO cancer vaccine has been tested in hundreds of patients with advanced forms of melanoma in Phase 2 clinical trials. The most recent data presented at an academic conference showed nearly 95% of people given only the vaccine were still alive three years after starting treatment and 64% were still disease-free. Among the most advanced forms of melanoma, disease-free survival after three years for people with stage III disease was 60% in the vaccine-only group, compared to about 39% in the placebo group. Disease-free survival for those with stage IV disease was about 68% in the vaccine-only group, and zero in the placebo group. The most common side effects were redness or pain at the injection site, fever and fatigue after the injection – similar to other vaccines that stimulate an immune response. Based on this data and other studies, the U.S. Food and Drug Administration has greenlit Wagner's vaccine to start a Phase 3 clinical trial. It will be a three-year endeavor with a goal to enroll 500 people and is planned to launch sometime this year, Riley Polk, president of Orbis Health Solutions, told WLOS, an ABC News affiliate in Asheville, North Carolina. Polk's own father was told there were no treatment options left for his lung cancer, according to the article. That was more than 10 years ago, and "His father opted to try Wagner's cancer vaccine and lived 10 more years before dying from something unrelated to cancer." Polk gives ABC News this quote. "You can tell me a lot of things, but you can't tell me [the vaccine] doesn't work."

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"Some of the most convenient fast-charging stations — mostly those located off major highways — have become gridlocked, especially on busy weekends," complains the opinion editor for California's Tribune newspaper in San Luis, Obispo. Drivers are reporting waits of half an hour or more — sometimes much more. One driver who posted on Reddit waited three hours to charge in Kettleman City on Thanksgiving weekend, turning a five-and-a-half-hour trip into a 10-and-a-half-hour ordeal... Look, it's one thing to spend 30 or 40 minutes charging a battery, which is a given when you take an EV on a road trip. But having to wait in a long line just to get to an open charging bay? What's happening now is "potentially a nightmare for drivers as more EVs hit the road," described GreenBiz transportation writer Vartan Badalian [after a March visit to New York State]... Badalian, the transportation writer, has an idea on how to deal with gridlock. "As you approach a full charging location, your EV (of any make) connects to the charging location and enters itself into a virtual queue, with entry to the queue dependent upon close geographical proximity. Drivers then park in an available normal parking spot, and only when prompted, proceed to plug in and charge. If a driver attempted to charge before their turn, the chargers would simply not communicate with the vehicle..." If only that would work. Unfortunately, plug-in chargers have a tough enough time fulfilling their basic task of delivering electricity. Hereâ(TM)s how bad it is: A survey of non-Tesla chargers conducted in the Bay Area in 2022 found that 27% of chargers were not working. This would be a good time to point out that Tesla superchargers have a much better performance record than other types of chargers, and that Tesla is opening "select" supercharger stations to other types of vehicles. Also, efforts are being made to increase the reliability of public chargers; the U.S. Department of Transportation just awarded $149 million in grants for the repair and replacement of broken chargers. The biggest share, $64 million, is going to California. In other words, hope is on the horizon. For now, though, we seem to be relying on a haphazard honor system. How hard would it be to use some orange cones to designate a "waiting lane"? That way drivers pulling in could get an immediate read on how long they might have to wait... Also, limit drivers to an 80% charge, and require them to drive away within, say, five minutes after the charger has stopped. That might be hard to enforce, but peer pressure can be a powerful incentive. The point is, somebody has to step up and make charging stations more driver-friendly, and the obvious choice is whoever is in charge of the chargers.

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"Good news..." NASA posted Saturday night on X. "We've reestablished contact with the Mars Helicopter..." After a two-day communications blackout, NASA had instructed its Perseverance Mars rover "to perform long-duration listening sessions for Ingenuity's signal" — and apparently they did the trick. "The team is reviewing the new data to better understand the unexpected comms dropout" during the helicopter's record-breaking 72nd flight. Slashdot reader Thelasko shared this report from NPR: Communications broke down on Thursday, when the little autonomous rotorcraft was sent on a "quick pop-up vertical flight," to test its systems after an unplanned early landing during its previous flight, the agency said in a status update on Friday night. The Perseverance rover, which relays data between the helicopter and Earth during the flights, showed that Ingenuity climbed to its assigned maximum altitude of 40 feet, NASA said. During its planned descent, the helicopter and rover stopped communicating with each other... Even before it came back online, RockDoctor (Slashdot reader #15,477) pointed out that the Mars copter has done this before. "Batteries dieing, resulting in a communications re-set, If I remember correctly." Space.com also noted additional alternatives: "Perseverance is currently out of line-of-sight with Ingenuity, but the team could consider driving closer for a visual inspection," NASA's Jet Propulsion Laboratory in Southern California, which manages both robots' missions, said via X on Friday. Ingenuity has stayed aloft for more than 128 minutes and covered a total of 11 miles (17.7 kilometers) during its 72 Mars flights, according to the mission's flight log.

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"It's ridiculous just how virulent some of these bacteria get over time," says Dwayne Roach, assistant professor of bacteriophages, infectious disease and immunology at San Diego State University. But now CNN says doctors are fighting multi-drug-resistant superbugs with "nature's oldest predators — tiny tripod-looking viruses called phages designed to find, attack and gobble up bacteria." The microscopic creatures have saved the lives of patients dying from superbug infections and are being used in clinical trials as a potential solution to the growing problem of antibiotic resistance... In labs around the country, phage scientists are taking research and discovery to the next level... [Yale scientists] are busy mapping which phages and antibiotics are most symbiotic in the fight against a pathogen. Roach's San Diego State lab is investigating the body's immune response to phages while developing new phage purification techniques to prepare samples for intravenous use in patients. Currently, clinical trials are underway to test the effectiveness of phages against intractable urinary tract infections, chronic constipation, joint infections, diabetic foot ulcers, tonsillitis and the persistent, reoccurring infections that occur in patients with cystic fibrosis. The chronic infections common in cystic fibrosis are typically due to various strains of drug-resistant Pseudomonas aeruginosa — the same pathogen responsible for Horton's ear infection and the artificial tears outbreak. A number of labs are developing libraries of phages, stockpiled with strains found in nature that are known to be effective against a particular pathogen. In Texas, a new facility is taking that a step further — speeding up evolution by creating phages in the lab. "Rather than just sourcing new phages from the environment, we have a bioreactor that in real time creates billions upon billions of phages," said Anthony Maresso, associate professor at Baylor College of Medicine in Houston. "Most of those phages won't be active against the drug-resistant bacteria, but at some point there will be a rare variant that has been trained, so to speak, to attack the resistant bacteria, and we'll add that to our arsenal," Maresso said. "It's a next-generation approach on phage libraries." Maresso's lab published a study last year on the treatment of 12 patients with phages customized to each patient's unique bacterial profile. It was a qualified success: The antibiotic-resistant bacteria in five patients were eradicated, while several more patients showed improvements. "There's a lot of approaches right now that are happening in parallel," Roach said. "Do we engineer phages? Do we make a phage cocktail, and then how big is the cocktail? Is it two phages or 12 phages? Should phages be inhaled, applied topically or injected intravenously? There's a lot of work underway on exactly how to best do this...." Genetically engineering phages would allow scientists to target each person's unique mix of antibiotic-resistant pathogens instead of searching sewage, bogs, ponds, the bilge of boats and other prime breeding grounds for bacteria to find just the right phage for the job. Along with phage libraries, genetic engineering is also a key to churning out phages in mass, to distribute on a wider scale. In Russia and the country of Georgia, where phage therapy has been used for decades, patients can buy phage cocktails off the shelf in pharmacies.

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"A familiar shadow looms in a fresh image of the heart of the nearby galaxy M87," reports Science magazine. "It confirms that the galaxy harbors a gravitational sinkhole so powerful that light cannot escape, one generated by a black hole 6.5 billion times the mass of the Sun." But compared with a previous image from the network of radio dishes called the Event Horizon Telescope (EHT), the new one reveals a subtle shift in the bright ring surrounding the shadow, which could provide clues to how gases churn around the black hole. "We can see that shift now," says team member Sera Markoff of the University of Amsterdam. "We can start to use that." The new detail has also whetted astronomers' desire for a proposed expansion of the EHT, which would deliver even sharper images of distant black holes. The new picture, published this week in Astronomy & Astrophysics, comes from data collected 1 year after the observing campaign that led to the first-ever picture of a black hole, revealed in 2019 and named as Science's Breakthrough of the Year. The dark center of the image is the same size as in the original image, confirming that the image depicts physical reality and is not an artifact. "It tells us it wasn't a fluke," says Martin Hardcastle, an astrophysicist at the University of Hertfordshire who was not involved in the study. The black hole's mass would not have grown appreciably in 1 year, so the comparison also supports the idea that a black hole's size is determined by its mass alone. In the new image, however, the brightest part of a ring surrounding the black hole has shifted counterclockwise by about 30 degrees. That could be because of random churning in the disk of material that swirls around the black hole's equator. It could also be associated with fluctuations in one of the jets launched from the black hole's poles — a sign that the jet isn't aligned with the black hole's spin axis, but precesses around it like a wobbling top. That would be "kind of exciting," Markoff says. "The only way to know is to keep taking pictures...." [T]he team wants to add more telescopes to the network, which would further sharpen its images and enable it to see black holes in more distant galaxies. Thanks to Slashdot reader sciencehabit for sharing the news.

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"After a year in which both actors and writers hit the picket lines, another Hollywood strike may be on the horizon," reports CNN: The American Federation of Musicians (AFM), a union representing musicians across the entertainment industry, will begin negotiations Monday on a new contract with the Alliance of Motion Picture and Television Producers (AMPTP). The union said it is seeking a deal to better reflect the current state of streaming media. The AFM is also seeking AI protection, increased wages, health care improvements, improved working conditions and residual payments for streaming content. According to the AFM, musicians who record on soundtracks make 75% less on streaming content due to less residual income. "The entertainment industry has fundamentally shifted," the union said in a news release. But musicians "are not being compensated accordingly for streaming media." AFM's president and chief negotiator Tino Gagliardi told CNN the union "is going to be prepared to do whatever it needs to get what we have to have, in order to make the lives of musicians better..." The AFM says it has roughly 70,000 members in the United States and Canada. Members include instrumental musicians working in orchestras, bands, clubs and theater who create music for film, television, commercials and other mediums.

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An anonymous reader shared this report from the Register: Two weeks before Apple launched the Macintosh, Sir Clive Sinclair launched his unprecedentedly powerful yet affordable Motorola-powered SOHO computer — starting a line of hardware and software that, remarkably, is still going. The QL remains a much-misunderstood computer. For its time, it was just as radical as the closely related machine that launched days later. Although it wasn't a smash hit, it wasn't the failure it's often deemed. A multinational licensed Sinclair's hardware, and several big-name companies sold versions of it around the world. The QL also inspired a dozen software-compatible successors, at least one of which is still manufactured today ... and not one but two versions of its unique operating system are still around as open source. Sinclair Research launched the QL on January 12, 1984, nearly two weeks before Apple Computer launched its new Macintosh computer on the 24th. Both machines had Motorola 68000-family processors, a mere 128 kB of memory, and just a pair of serial ports for I/O. Both launched with powerful bundled applications. Both had brutally cut-down specifications to make them price competitive, and both were big technological gambles on unproven technology, previously only available in vastly more expensive computers. Sinclair's bet was that multitasking would be the key differentiator. It was the first affordable personal computer to offer this. Today it's clear that Sinclair backed the wrong horse, but four decades ago, its mistake was understandable. Before the Macintosh, it was not at all clear that GUIs were the future... When the QL turned 30, The Reg published a detailed history, but a decade on, we thought it would be more interesting to look at the legacy of this pioneering machine — the many models of QL-compatible machines that appeared after Sinclair Research moved on to other things, and the descendants of its remarkable OS and their continued existence in the 21st century.

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"Would you pay $15 a month so Android doesn't track you and send all of that data back to Google?" asks Stuff South Africa: A new Swiss-based privacy company thinks $15 is a fair fee for that peace of mind. "A person's data is the original digital currency," argues Apostrophy, which has created its own operating system, called Apostrophy OS. It's based on Android — don't panic — but the version that has already been stripped of Google's intrusiveness by another privacy project called GrapheneOS, which used to be known as CopperheadOS. Launched in 2014, it which was briefly known as the Android Hardening project, before being rebranded as GrapheneOS in 2019. Apostrophy OS is "focused on empowering our users, not leveraging them," it says and is "purposely Swiss-based, so we can be champions of data sovereignty". What it does, they say, is separate the apps from the underlying architecture of the operating system and therefore prevent apps from accessing miscellaneous personal data, especially the all-important location data so beloved of surveillance capitalism... Apostrophy OS has its own app store, but also cleverly allows users to access the Google Play Store. If you think that is defeating the point, Apostrophy argues that those apps can't get to the vitals of your digital life. Apostrophy OS has "partitioned segments prioritising application integrity and personal data privacy". The service is free for one year with the purchase of the new MC02 phone from Swiss manufacturer Punkt, according to PC Magazine. "The phone costs $749 and is available for preorder now. It will ship at the end of January." Additional features include a built-in VPN called Digital Nomad based on the open-source Wireguard framework to secure your activity against outside snooping, which includes "exit addresses" in the US, Germany, and Japan with the base subscription.

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An anonymous reader shared this report from Time: An AI customer service chatbot for international delivery service DPD used profanity, told a joke, wrote poetry about how useless it was, and criticized the company as the "worst delivery firm in the world" after prompting by a frustrated customer. Ashley Beauchamp, a London-based pianist and conductor, according to his website, posted screenshots of the chat conversation to X (formerly Twitter) on Thursday, the same day he said in a comment that the exchange occurred. At the time of publication, his post had gone viral with 1.3 million views, and over 20 thousand likes... The recent online conversation epitomizing this debate started mid-frustration as Beauchamp wrote "this is completely useless!" and asked to speak to a human, according to a recording of a scroll through the messages. When the chatbot said it couldn't connect him, Beauchamp decided to play around with the bot and asked it to tell a joke. "What do you call a fish with no eyes? Fsh!" the bot responded. Beauchamp then asked the chatbot to write a poem about a useless chatbot, swear at him and criticize the company--all of which it did. The bot called DPD the "worst delivery firm in the world" and soliloquized in its poem that "There was once a chatbot called DPD, Who was useless at providing help." "No closer to finding my parcel, but had an entertaining 10 minutes with this chatbot ," Beauchamp posted on X. (Beauchamp also quipped that "The future is here and it's terrible at poetry.") A spokesperson for DPD told the BBC, "We have operated an AI element within the chat successfully for a number of years," but that on the day of the chat, "An error occurred after a system update... The AI element was immediately disabled and is currently being updated."

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