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Musk's moonshot still missing orbit, refueling, landing

Comment SpaceX is celebrating two consecutive Starship launches without unplanned explosions, yet the business faces a daunting path forward before the spacecraft can deliver astronauts to the lunar surface.…

Oracle slurps your data whether you like it or not... for the good and bad of the planet

Comment If you're an Oracle customer – throw a pebble into a crowd of 100 CIOs and you're bound to hit one – then Big Red has vectorized you. Or, more accurately, it has vectorized your data, according to Larry Ellison, co-founder and CTO, who lobbed about the terminology in this week's conference keynote as if it conferred some sort of mystical technological incantation.…

Windows 10 is the least of some people's problems

Windows 10's free support has shuffled off this mortal coil for most customers – but that's merely the headline act in Microsoft's October support massacre. Older versions of Office and Windows Server have also been shown the door.…

Scientists from Spain and China have successfully repaired the blood-brain barrier in Alzheimer's-model mice, enabling the brain to naturally clear amyloid-beta plaques and reverse cognitive decline. "After just three drug injections, mice with certain genes that mimic Alzheimer's showed a reversal of several key pathological features," adds ScienceAlert. From the report: Within hours of the first injection, the animal brains showed a nearly 45 percent reduction in clumps of amyloid-beta plaques, a hallmark of Alzheimer's disease. The mice had previously shown signs of cognitive decline, but after all three doses, the animals performed on par with their healthy peers in spatial learning and memory tasks. The benefits lasted at least six months. These preclinical results don't guarantee success in humans, but they're an encouraging start, which the authors say "heralds a new era" in drug research. "The therapeutic implications are profound," claim the international team of researchers, co-led by scientists at the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital Sichuan University (WCHSU). The findings have been published in Signal Transduction and Targeted Therapy.

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Minister pins hopes on low Earth orbit satellites to plug crap rail connectivity

Data-hungry rail passengers will have to wait until at least 2030 before getting something like universal mobile data coverage across the UK, a minister confirmed this week.…

An anonymous reader quotes a report from the Conversation: Sound waves at frequencies above the threshold for human hearing are routinely used in medical care. Also known as ultrasound, these sound waves can help clinicians diagnose and monitor disease, and can also provide first glimpses of your newest family members. And now, patients with conditions ranging from cancer to neurodegenerative diseases like Alzheimer's may soon benefit from recent advances in this technology. I am a biomedical engineer who studies how focused ultrasound -- the concentration of sound energy into a specific volume -- can be fine-tuned to treat various conditions. Over the past few years, this technology has seen significant growth and use in the clinic. And researchers continue to discover new ways to use focused ultrasound to treat disease. [...] Research on focused ultrasound has primarily focused on the most devastating and prevalent diseases, such as cancer and Alzheimer's disease. However, I believe that further developments in, and increased use of, focused ultrasound in the clinic will eventually benefit patients with rare diseases. One rare disease of particular interest for my lab is cerebral cavernous malformation, or CCM. CCMs are lesions in the brain that occur when the cells that make up blood vessels undergo uncontrolled growth. While uncommon, when these lesions grow and hemorrhage, they can cause debilitating neurological symptoms. The most common treatment for CCM is surgical removal of the brain lesions; however, some CCMs are located in brain areas that are difficult to access, creating a risk of side effects. Radiation is another treatment option, but it, too, can lead to serious adverse effects. We found that using focused ultrasound to open the blood-brain barrier can improve drug delivery to CCMs. Additionally, we also observed that focused ultrasound treatment itself could stop CCMs from growing in mice, even without administering a drug. While we don't yet understand how focused ultrasound is stabilizing CCMs, abundant research on the safety of using this technique in patients treated for other conditions has allowed neurosurgeons to begin designing clinical trials testing the use of this technique on people with CCM. With further research and advancements, I am hopeful that focused ultrasound can become a viable treatment option for many devastating rare diseases.

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