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Asia In Brief Australia’s University of Melbourne last year used Wi-Fi location data to identify student protestors.…

"For a few dozen people in the world, the downside of living with a rare immune condition comes with a surprising superpower — the ability to fight off all viruses..." notes an announcement from Columbia University. "At first, the condition only seemed to increase vulnerability to some bacterial infections. But as more patients were identified, its unexpected antiviral benefits became apparent." Columbia immunologist Dusan Bogunovic discovered the individuals' antiviral powers about 15 years ago, soon after he identified the genetic mutation that causes the condition... Bogunovic, a professor of pediatric immunology at Columbia University's Vagelos College of Physicians and Surgeons, soon learned that everyone with the mutation, which causes a deficiency in an immune regulator called ISG15, has mild, but persistent systemic inflammation... "In the back of my mind, I kept thinking that if we could produce this type of light immune activation in other people, we could protect them from just about any virus," Bogunovic says. Today, Bogunovic is closing in on a therapeutic strategy that could provide that broad-spectrum protection against viruses and become an important weapon in next pandemic. In his latest study, published August 13 in Science Translational Medicine, Bogunovic and his team report that an experimental therapy they've developed temporarily gives recipients (hamsters and mice, so far) the same antiviral superpower as people with ISG15 deficiency. When administered prophylactically into the animals' lungs via a nasal drip, the therapy prevented viral replication of influenza and SARS-CoV-2 viruses and lessened disease severity. In cell culture, "we have yet to find a virus that can break through the therapy's defenses," Bogunovic says... Bogunovic's therapeutic turns on production of 10 proteins that are primarily responsible for the broad antiviral protection. The current design resembles COVID mRNA vaccines but with a twist: Ten mRNAs encoding the 10 proteins are packaged inside a lipid nanoparticle. Once the nanoparticles are absorbed by the recipient's cells, the cells generate the ten host proteins to produce the antiviral protection. "We only generate a small amount of these ten proteins, for a very short time, and that leads to much less inflammation than what we see in ISG15-deficient individuals," Bogunovic says. "But that inflammation is enough to prevent antiviral diseases...." "We believe the technology will work even if we don't know the identity of the virus," Bogunovic says. Importantly, the antiviral protection provided by the technology will not prevent people from developing their own immunological memory to the virus for longer-term protection. "Our findings reinforce the power of research driven by curiosity without preconceived notions," Bogunovic says in the announcement. "We were not looking for an antiviral when we began studying our rare patients, but the studies have inspired the potential development of a universal antiviral for everyone." More coverage from ScienceAlert.

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"A fierce dust storm hit the Black Rock Desert on the eve of its annual Burning Man festival," reports the San Francisco Chronicle, "causing at least four minor injuries and damaging campsites that had been set up early." [Alternate URL] "Winds of up to 50 mph stirred up the lake bed's alkaline dust so ferociously that participants in the annual art and culture festival reported not being able to see beyond a foot... " The dust storm arrived Saturday evening after strong thunderstorms in the Sierra Nevada drifted off the mountains and whipped up strong winds in the Nevada desert... At 5:14 p.m. Saturday, the weather service issued a dust storm advisory for Black Rock City and warned of "a wall of blowing dust coming off the Smoke Creek and Black Rock Desert playa areas is tracking northward at around 30 mph." The agency warned of visibility less than 1 mile and wind gusts exceeding 45 mph. A weather station at Black Rock City Airport measured gusts up to 52 mph at 5:50 p.m... ["We saw structures being ripped and torn down by the wind speeds even though we buttoned everything down as best as we could..." one Burner told the Chronicle.] Camp residents posted a slew of videos to social media featuring dust tornadoes, destroyed campsites, and fellow campers struggling to hold onto bucking canvases as the wind threatened to rip them away. "Every popup canopy I've seen has been destroyed," one Burner wrote on Reddit... ["Make sure you carry your particle/dust mask and goggles with you when you venture out on playa!" warns Burning Man's official weather page.] Even after Saturday's storm, Burners won't be out of the woods from hazardous weather. The weather service warned of possible monsoon thunderstorms and heavy rain Sunday through Wednesday, raising concerns that this year's festival could echo disastrous 2023 conditions, when heavy storms stranded tens of thousands of attendees amid thick mud. "It's becoming increasingly likely that we could see an even greater flash flood threat," the weather service wrote in an online forecast. "If you're on the playa at the Black Rock Desert, you may very well be in for a muddy mess Monday through Wednesday." Slow-moving storms could drop an inch of rain or more in a short period. "Still, gates to the festival had opened by Sunday morning," the article adds, "with organizers cautioning new arrivals to 'drive safely!'" Burning Man's official weather page currently links to a National Weather Service page with a "Flood Watch" warning through 9 p.m. Sunday, and also predicting a chance of thunderstorms on Sunday and Monday.

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