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Doctors report the first successful treatment for Huntington's disease using a new type of gene therapy given during 12 to 18 hours of delicate brain surgery. The BBC reports: An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients. It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of "good quality life", Prof Sarah Tabrizi told BBC News. The first symptoms of Huntington's disease tend to appear in your 30s or 40s and is normally fatal within two decades -- opening the possibility that earlier treatment could prevent symptoms from ever emerging. None of the patients who have been treated are being identified, but one was medically retired and has returned to work. Others in the trial are still walking despite being expected to need a wheelchair. Treatment is likely to be very expensive. However, this is a moment of real hope in a disease that hits people in their prime and devastates families. [...] It starts with a safe virus that has been altered to contain a specially designed sequence of DNA. This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions - the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery. The virus then acts like a microscopic postman -- delivering the new piece of DNA inside brain cells, where it becomes active. This turns the neurons into a factory for making the therapy to avert their own death. The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells' DNA for building mutant huntingtin. This results in lower levels of mutant huntingtin in the brain. [...] The data showed that three years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life. The data also shows the treatment is saving brain cells. Levels of neurofilaments in spinal fluid -- a clear sign of brain cells dying -- should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.

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By supporting efficient video codecs in hardware, which to be fair will also help punters

Google, Meta, and Vodafone have called on chipmakers and smartphone manufacturers to support the AV1 video codec in hardware, especially in midrange devices, a suggestion that’s not entirely altruistic.…

As ban on under-16s using some sites looms, cyber-safety regulator sends Microsoft’s code locker a letter

Australia’s eSafety Commissioner has written to GitHub to ask it to consider if it’s a social network that endangers children.…

An anonymous reader quotes a report from The Guardian: The world's oceans have failed a key planetary health check for the first time, primarily due to the burning of fossil fuels, a report has shown. In its latest annual assessment, the Potsdam Institute for Climate Impact Research said ocean acidity had crossed a critical threshold for marine life. This makes it the seventh of nine planetary boundaries to be transgressed, prompting scientists to call for a renewed global effort to curb fossil fuels, deforestation and other human-driven pressures that are tilting the Earth out of a habitable equilibrium. The report, which follows earlier warnings about ocean acidity, comes at a time of recordbreaking ocean heat and mass coral bleaching. Oceans cover 71% of the Earth's surface and play an essential role as a climate stabilizer. The new report calls them an "unsung guardian of planetary health", but says their vital functions are threatened. The 2025 Planetary Health Check noted that since the start of the industrial era, oceans' surface pH has fallen by about 0.1 units, a 30-40% increase in acidity, pushing marine ecosystems beyond safe limits. Cold-water corals, tropical coral reefs and Arctic marine life are especially at risk. This is primarily due to the human-caused climate crisis. When carbon dioxide from oil, coal and gas burning enters the sea, it forms carbonic acid. This reduces the availability of calcium carbonate, which many marine organisms depend upon to grow coral, shells or skeletons. Near the bottom of the food chain, this directly affects species like oysters, molluscs and clams. Indirectly, it harms salmon, whales and other sea life that eat smaller organisms. Ultimately, this is a risk for human food security and coastal economies. Scientists are concerned that it could also weaken the ocean's role as the planet's most important heat absorber and its capacity to draw down 25-30% of the carbon dioxide in the atmosphere. Marine life plays an important role in this process, acting as a "biotic bump" to sequester carbon in the depths. In the report, all of the other six breached boundaries -- climate change, biosphere integrity, land system change, freshwater use, biogeochemical flows, and novel entities -- showed a worsening trend. But the authors said the addition of the only solely ocean-centerd category was a alarming development because of its scale and importance.

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More datacenters in familiar territories, too, and AI everywhere

Alibaba Cloud yesterday announced its first datacenters in Brazil, France, and The Netherlands, plus expansion of its presence in five other countries outside China.…

Intel has approached Apple about a possible investment and closer collaboration, following recent multibillion-dollar deals with Nvidia, the U.S. government, and SoftBank to stabilize the struggling chipmaker. Reuters reports: The iPhone maker and Intel have also discussed how to work more closely together, the report said, adding that the talks are at an early stage and may not lead to an agreement. Shares of Intel closed 6% higher after the news. [...] Striking lucrative partnerships and persuading outside clients to use Intel's factories remain key to its future. Intel has also reached out to other companies about possible investments and partnerships, according to the Bloomberg News report. The reported investment from Apple would come as another vote of confidence for Intel - Apple had been a longtime customer of Intel before it transitioned to using its own custom-designed silicon chips in 2020. For Apple, which relies heavily on Intel's rival TSMC to manufacture its chips, the new partnership would allow it to diversify its chipmaking supplier base - a move that would be valuable if geopolitical risks in Taiwan worsen due to China's role in the region. It would also help Apple improve its relationship with U.S. President Donald Trump, by showing that it is investing in the United States - while much of Apple's supply chain remains international, the company has committed about $600 billion to domestic initiatives over the next four years.

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Qualcomm unveiled its Snapdragon X2 Elite and Extreme chips, claiming they're the "fastest and most efficient processors for Windows PCs." Built on 3nm with up to 18 cores and a 5GHz Arm CPU boost, the chips promise 31% more CPU power, up to 2.3x GPU performance, stronger AI processing, and "multi-day battery life," with devices expected in the first half of 2026. The Verge reports: There's also a new 80 TOPS Hexagon NPU, for AI tasks, that offers 37 percent more performance with a 16 percent power consumption improvement, the company claims. Qualcomm's characterizing all of this as a "legendary leap in performance," claiming the Elite Extreme in particular offers "up to 75 percent faster CPU performance" at the same power. But it doesn't say who the competition is, or which chip it was up against, at least not in the press release. And while Qualcomm claims these power savings will lead to "multi-day battery life," that's also what the company said about last year's Snapdragon X Elite.

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Redmond wants more flavors of ML than OpenAI can cook up

Microsoft has sealed a deal with Anthropic to give users of Microsoft 365 Copilot the option to use the Claude AI engine.…

Neon Mobile, now the No. 2 social networking app in Apple's U.S. App Store, pays users up to $30 per day to record their phone calls and sell the data to AI companies. The app claims to only capture one side of a call unless both parties use Neon, but its terms grant sweeping rights over recordings. TechCrunch reports: The app, Neon Mobile, pitches itself as a money-making tool offering "hundreds or even thousands of dollars per year" for access to your audio conversations. Neon's website says the company pays 30 cents per minute when you call other Neon users and up to $30 per day maximum for making calls to anyone else. The app also pays for referrals. According to Neon's terms of service, the company's mobile app can capture users' inbound and outbound phone calls. However, Neon's marketing claims to only record your side of the call unless it's with another Neon user. That data is being sold to "AI companies," the company's terms of service state, "for the purpose of developing, training, testing, and improving machine learning models, artificial intelligence tools and systems, and related technologies." Despite what Neon's privacy policy says, its terms include a very broad license to its user data, where Neon grants itself a: "...worldwide, exclusive, irrevocable, transferable, royalty-free, fully paid right and license (with the right to sublicense through multiple tiers) to sell, use, host, store, transfer, publicly display, publicly perform (including by means of a digital audio transmission), communicate to the public, reproduce, modify for the purpose of formatting for display, create derivative works as authorized in these Terms, and distribute your Recordings, in whole or in part, in any media formats and through any media channels, in each instance whether now known or hereafter developed." That leaves plenty of wiggle room for Neon to do more with users' data than it claims. The terms also include an extensive section on beta features, which have no warranty and may have all sorts of issues and bugs. Peter Jackson, cybersecurity and privacy attorney at Greenberg Glusker, told TechCrunch: "Once your voice is over there, it can be used for fraud. Now, this company has your phone number and essentially enough information -- they have recordings of your voice, which could be used to create an impersonation of you and do all sorts of fraud."

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