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In February, a six-month-old baby named KJ Muldoon became the first person ever to receive a CRISPR gene-editing treatment customized specifically for his unique genetic mutation, a milestone that researchers say marks a turning point in how medicine might approach the thousands of rare diseases that collectively affect 30 million Americans. Muldoon was born with a type of urea-cycle disorder that gives patients roughly a 50% chance of surviving infancy and typically requires a liver transplant; he is now a healthy 1-year-old who recently took his first steps. The treatment's significance extends beyond one child. Scientists at UC Berkeley's Innovative Genomics Institute and the Children's Hospital of Philadelphia are now planning clinical trials that would use Muldoon's therapy as a template, tweaking the molecular "address" in the CRISPR system to target different mutations in other children with urea-cycle disorders. Last month, FDA officials Marty Makary and Vinay Prasad announced a new drug pathway designed to accelerate approvals for such personalized treatments -- a framework inspired in large part by Muldoon's case. Current gene-editing delivery mechanisms limit treatments to disorders in the blood and liver. Many families will still go without bespoke therapies.

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Brussels probes whether unpaid web and YouTube content – and rivals' lock-outs – amount to abuse of dominance

The European Commission is launching an antitrust probe at Google for allegedly using web and YouTube content to train its AI algorithms while putting competitors at a disadvantage.…

As Trump gives green light to ship Nvidia H200s to China and boost US

Three US-based businessmen face potential prison sentences after authorities dismantled a smuggling network accused of funneling hundreds of millions of dollars worth of Nvidia GPUs to China.…

A tenured USC professor is arguing that universities need to fundamentally rethink their value proposition as AI rapidly closes the gap on human instruction and a loneliness epidemic grips the generation most likely to be sitting in their lecture halls. Eric Anicich, an associate professor at USC's Marshall School of Business, wrote in the Los Angeles Times that nearly three-quarters of 16- to 24-year-olds now report feeling lonely, young adults spend 70% less time with friends in person compared to two decades ago, and a growing majority of Gen Z college graduates say their degree was a "waste of money." Anicich points to a recent Harvard study finding that students using an AI tutor learned more than twice as much as those in traditional active-learning classes, and did so in less time. The implication is stark: if instruction becomes abundant and cheap, colleges must sell what remains scarce -- genuine human community. He notes that his doctoral training included zero coursework on teaching, a norm he says persists across academia. His proposal: fund student life as seriously as research labs, hire professional "experience designers," and treat rituals and collaborative projects as core curriculum rather than amenities.

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Have we learned nothing from sci-fi films and TV shows?

Interview Imagine botnets in physical form and you've got a pretty good idea of what could go wrong with the influx of AI-infused humanoid robots expected to integrate into society over the next few decades.…

Microsoft Excel, the 40-year-old spreadsheet application that helped establish personal computers as essential workplace tools and contributed to Microsoft's current valuation of nearly $4 trillion, has weathered both the rise of cloud computing and the current AI boom largely unscathed. In its most recent quarter, commercial revenue for Microsoft 365 -- the bundle including Excel, Word, and PowerPoint -- increased 17% year over year, and consumer revenue rose 28%. The software traces its origins to a 1983 Microsoft offsite under the code name Odyssey, where engineers set out to clone Lotus 1-2-3. That program had itself cloned VisiCalc, the first computerized spreadsheet, created by Dan Bricklin for the Apple II in the late 1970s. Bricklin never patented VisiCalc. "Financially it would have been great if we'd have been able to patent it," he told Bloomberg. "And there would be a Bricklin Building at MIT, instead of a Gates Building." Excel now counts an estimated 500 million paying users. The Pentagon pays for 2 million Microsoft 365 licenses. Google's free Sheets product, launched in 2006, captured casual use cases like potluck sign-ups but failed to dislodge Excel from enterprise work. AI chatbots present the latest challenge, but venture capitalists say nearly every AI spreadsheet startup they meet builds on top of Excel rather than replacing it.

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Billionaire's bid progresses while agency braces for sweeping reductions and program uncertainty

Jared Isaacman has cleared another hurdle on his way to becoming the next NASA Administrator after the US Senate Committee on Commerce, Science, and Transportation gave the billionaire SpaceX customer the nod.…

India's dominant airline IndiGo has cancelled roughly 3,000 flights since last week after new pilot fatigue regulations collided with technical issues and the seasonal schedule shift, stranding more than half a million passengers and forcing aviation authorities to reverse course on the safety rules they had just implemented. InterGlobe Aviation, IndiGo's parent company, told regulators that stricter requirements for night flying and weekly rest periods created an acute crew shortage. The Airline Pilots Association of India called the regulatory rollback a "dangerous precedent," noting that management had known about the requirements since early last year. IndiGo controls 65.6% of India's domestic aviation market as of October 2025 and briefly became the world's most valuable airline in April. The crisis arrives as India's second-largest carrier, Air India, remains under investigation following a June crash that killed 241 passengers and crew. Authorities have imposed temporary price caps to prevent gouging.

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Analysts say demand keeps rising despite constraints, shaky returns, and mounting investor nerves

Datacenter capital expenditure is forecast to grow 17 percent annually through 2030, reaching $1.6 trillion, with supply chain constraints pushing up the price of components.…

February product launch fails to register, with concerns remaining about integration

SAP users admit they know very little about the vendor's data and analytics plans since the launch of the new product platform, Business Data Cloud (BDC), in February.…

An anonymous reader quotes a report from the Guardian: The journal Regulatory Toxicology and Pharmacology has formally retracted a sweeping scientific paper published in 2000 that became a key defense for Monsanto's claim that Roundup herbicide and its active ingredient glyphosate don't cause cancer. Martin van den Berg, the journal's editor in chief, said in a note accompanying the retraction that he had taken the step because of "serious ethical concerns regarding the independence and accountability of the authors of this article and the academic integrity of the carcinogenicity studies presented." The paper, titled Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans, concluded that Monsanto's glyphosate-based weed killers posed no health risks to humans -- no cancer risks, no reproductive risks, no adverse effects on development of endocrine systems in people or animals. Regulators around the world have cited the paper as evidence of the safety of glyphosate herbicides, including the Environmental Protection Agency (EPA) in this assessment (PDF). [...] In explaining the decision to retract the 25-year-old research paper, Van den Berg wrote: "Concerns were raised regarding the authorship of this paper, validity of the research findings in the context of misrepresentation of the contributions by the authors and the study sponsor and potential conflicts of interest of the authors." He noted that the paper's conclusions regarding the carcinogenicity of glyphosate were solely based on unpublished studies from Monsanto, ignoring other outside, published research. "The retraction of this study is a long time coming," said Brent Wisner, one of the lead lawyers in the Roundup litigation and a key player in getting the internal documents revealed to the public. Wisner said the study was the "quintessential example of how companies like Monsanto could fundamentally undermine the peer-review process through ghostwriting, cherrypicking unpublished studies, and biased interpretations." "This garbage ghostwritten study finally got the fate it deserved,â Wisner added. "Hopefully, journals will now be more vigilant in protecting the impartiality of science on which so many people depend."

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Foreign secretary set to address senior diplomats later today

The UK's foreign secretary is calling for closer collaboration with Europe to combat the growing threat of information warfare as hybrid attacks target countries on the continent.…

Younger finance pros are just as loyal to Microsoft's venerable spreadsheet app as their elders

Despite its advancing years, Microsoft Excel is proving a hit with young finance professionals, many of whom reckon the aging number-cruncher has a bright future.…

Digital native? Cloud native? No, we need to be AI native, says Riyadh Air

IBM and Riyadh Air have upgraded their contracted agreement, meaning the Saudi operation will not be the world's first digitally native airline, but will instead be the first AI native operator.…

UK data watchdog demands public sector improves subject access request processing

UK public sector organizations need to improve access for those who want to see their own records of growing up in care, the Information Commissioner says.…

As Portugal gives researchers a pass under cybersecurity law

Portugal has become the latest country to carve out protections for researchers under its cybersecurity law.…

Researchers and moderators are increasingly concerned that ChatGPT-style language is bleeding into everyday speech and writing. The topic has been explored in the past but "two new, more anecdotal reports, suggest that our chatbot dialect isn't just something that can be found through close analysis of data," reports Gizmodo. "It might be an obvious, every day fact of life now." Slashdot reader joshuark shares an excerpt from the report: Over on Reddit, according to a new Wired story by Kat Tenbarge, moderators of certain subreddits are complaining about AI posts ruining their online communities. It's not new to observe that AI-armed spammers post low-value engagement bait on social media, but these are spaces like r/AmItheAsshole, r/AmIOverreacting, and r/AmITheDevil, where visitors crave the scintillation or outright titillation of bona fide human misbehavior. If, behind the scenes, there's not really a grieving college student having her tuition cut off for randomly flying off the handle at her stepmom, there's no real fun to be had. The mods in the Wired story explain how they detect AI content, and unfortunately their methods boil down to "It's vibes." But one novel struggle in the war against slop, the mods say, is that not only are human-written posts sometimes rewritten by AI, but mods are concerned that humans are now writing like AI. Humans are becoming flesh and blood AI-text generators, muddying the waters of AI "detection" to the point of total opacity. As "Cassie" an r/AmItheAsshole moderator who only gave Wired her first name put it, "AI is trained off people, and people copy what they see other people doing." In other words, Cassie said, "People become more like AI, and AI becomes more like people." Meanwhile, essayist Sam Kriss just explored the weird way chatbots "write" for the latest issue of the New York Times Magazine, and he discovered along the way that humans have accidentally taken cues from that weirdness. After parsing chatbots' strange tics and tendencies -- such as overusing the word "delve" most likely because it's in a disproportional number of texts from Nigeria, where that word is popular -- Kriss refers to a previously reported trend from over the summer. Members of the U.K. Parliament were accused of using ChatGPT to write their speeches. The thinking goes that ChatGPT-written speeches contained the phrase "I rise to speak," an American phrase, used by American legislators. But Kriss notes that it's not just showing up from time to time. It's being used with downright breathtaking frequency. "On a single day this June, it happened 26 times," he notes. While 26 different MPs using ChatGPT to write speeches is not some scientific impossibility, it's more likely an example of chatbots, "smuggling cultural practices into places they don't belong," to quote Kriss again. So when Kriss points out that when Starbucks locations were closing in September, and signs posted on the doors contained tortured sentences like, "It's your coffeehouse, a place woven into your daily rhythm, where memories were made, and where meaningful connections with our partners grew over the years," one can't state with certainty that this is AI-generated text (although let's be honest: it probably is).

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Officials insist OBR relied on 'early estimate' and real figure won't emerge until next year

The head of the department delivering the UK government's digital identity scheme has rejected the £1.8 billion cost forecast by the Office for Budget Responsibility (OBR), but is not willing to provide an alternative until after a delayed consultation on the plans.…

Anthropic is bringing Claude Code directly into Slack, letting developers spin up coding sessions from chat threads and automate workflows without leaving the app. TechCrunch reports: Previously, developers could only get lightweight coding help via Claude in Slack -- like writing snippets, debugging, and explanations. Now they can tag @Claude to spin up a complete coding session using Slack context like bug reports or feature requests. Claude analyzes recent messages to determine the right repository, posts progress updates in threads, and shares links to review work and open pull requests. The move reflects a broader industry shift: AI coding assistants are migrating from IDEs (integrated development environment, where software development happens) into collaboration tools where teams already work. [...] While Anthropic has not yet confirmed when it would make a broader rollout available, the timing is strategic. The AI coding market is getting more competitive, and differentiation is starting to depend more on integration depth and distribution than model capability alone.

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Get your Hyper-V and VMware ESXi setups in order, people

Researchers at security software vendor Huntress say they’ve noticed a huge increase in ransomware attacks on hypervisors and urged users to ensure they’re as secure as can be and properly backed up.…