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If penicillin was discovered on moldy bread, who's to say the next miracle drug won't be born from AI hallucinations

Nvidia has teamed up with pharmaceutical heavyweight Eli Lilly to plow up to $1 billion into a research lab over the next five years to advance the development of foundation models for AI-assisted drug discovery.…

High-margin infrastructure kit takes precedence, leaving laptops and desktops wanting

Memory shortages will likely stunt PC shipments in 2026, as available supplies will not be able to meet demand thanks to memory makers chasing the lucrative AI infrastructure market instead.…

60 years ago today, ABC aired the first episode of its live-action Batman television series, introducing Adam West as the deadpan Caped Crusader in what became a pop culture phenomenon blending high-camp humor and cliffhanger thrills. The mid-season replacement ran for 120 episodes over three seasons before ending in March 1968.

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Digital signage is great, until it isn't

Bork!Bork!Bork! Windows activation is a tricky thing, particularly for digital signage that should be directing customers to in-store bargains but instead shows passersby that someone has yet to give Microsoft their pound of flesh.…

Survey finds security checks nearly doubled in a year as leaders wise up

The number of organizations that have implemented methods for identifying security risks in the AI tools they use has almost doubled in the space of a year.…

Doctors say they have achieved the previously impossible -- restoring sight and preventing blindness in people with a rare but dangerous eye conditon called hypotony. From a report: Moorfields hospital in London is the world's first dedicated clinic for the disorder and seven out of eight patients given the pioneering treatment have responded to the therapy, a pilot study shows. One of them -- the first-ever -- is Nicki Guy, 47, who is sharing her story exclusively with the BBC. She says the results are incredible: "It's life-changing. It's given me everything back. I can see my child grow up. "I've gone from counting fingers and everything being really blurry to being able to see." Currently, she can see and read most lines of letters on an eye test chart. She is one line away from what is legally required for driving - a massive change from being partially sighted, using a magnifying glass for anything close up and having to navigate around the house and outside largely using memory. "If my vision stays like this for the rest of my life it would be absolutely brilliant. I may not ever be able to drive again but I'll take that!" she says. With hypotony, pressure within the eyeball becomes dangerously low, leading it to cave in on itself.

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You can check out anytime you like, but please don’t ever leave

Google is aiming to turn Gemini into a one-stop personal shopper with what it hopes will become a global standard for agentic AI commerce, and it's already persuaded major retailers to let Google handle transactions without sending users to their websites. …

The dramatically larger corner radius Apple introduced in macOS 26 Tahoe has pushed the invisible resize hit target for windows mostly outside the window itself -- roughly 75% of the 19Ã--19 pixel clickable area now lies beyond the visible boundary. In previous macOS versions, about 62% of that resize target would fall inside the window corner. Apple removed the visible resize grippy-strip from window corners in Mac OS X 10.7 Lion in July 2011. The visual indicator had served two purposes: showing users where to click and signaling whether a window could be resized at all. Users since then have relied on muscle memory and the reasonable assumption that clicking near the inside corner would initiate a resize. DaringFireball's John Gruber advice: don't upgrade to macOS 26, or downgrade if you already have. he wrote Monday: "Why suffer willingly with a user interface that presents you with absurdities like window resizing affordances that are 75 percent outside the window?"

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Two new Linux GUIs – plus Phoenix, an experimental new X server in Zig

The new year brings releases from opposite ends of the Linux GUI spectrum: IceWM, an X11 window manager from the late 1990s, and Budgie, a newer full desktop environment that has gone Wayland-native.…

Agents must be 'safer and better than humans,' James Nettesheim tells The Reg

interview When it comes to security, AI agents are like self-driving cars, according to Block Chief Information Security Officer James Nettesheim.…

A major new review by the Cochrane collaboration -- an independent network of researchers -- evaluated 73 randomized controlled trials involving about 5,000 people with depression and found that exercise matched the effectiveness of both pharmacological treatments and psychological therapies. The biological mechanisms overlap considerably with antidepressants. "Exercise can help improve neurotransmitter function, like serotonin as well as dopamine and endorphins," said Dr. Stephen Mateka, medical director of psychiatry at Inspira Health. Dr. Nicholas Fabiano of the University of Ottawa added that exercise triggers the release of brain-derived neurotrophic factor, or BDNF, which he calls "Miracle-Gro for the brain." Exercise has been adopted as a first-line treatment in depression guidelines globally, though Fabiano noted it remains underutilized. The meta-analysis found that combining aerobic exercise and resistance training appeared more effective than aerobic exercise alone, and that 13 to 36 workouts led to improvements in depressive symptoms. Light to moderate exercise proved as beneficial as vigorous workouts, at least initially.

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Apple has struck a multi-year partnership with Google to power a more capable version of Siri using Gemini AI models, ending months of speculation about which company would help the iPhone maker catch up in the generative AI race. In a statement, Apple said it had determined after "careful evaluation" that "Google's technology provides the most capable foundation for Apple Foundation Models." The deal comes after Apple delayed its planned Siri AI upgrade last March, acknowledging that the project was taking "longer than we thought." Bloomberg had reported in August that Apple was in early talks with Google about using a custom Gemini model. Apple also explored potential partnerships with OpenAI, Anthropic and Perplexity, and CEO Tim Cook has said the company plans to integrate with more AI companies over time. The upgraded Siri is expected to perform actions on users' behalf and understand personal context.

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President Donald Trump revived a campaign pledge Friday night by calling for a one-year, 10% cap on credit card interest rates, a proposal that banking groups immediately opposed despite the industry's heavy donations to his 2024 campaign and support for his second-term agenda. Trump posted on Truth Social that he hoped the cap would be in place by January 20, one year after he took office, though he did not specify whether it would come through executive action or legislation. Americans currently pay between 19.65% and 21.5% interest on credit cards on average and carry roughly $1.23 trillion in credit card debt, according to the New York Federal Reserve. Researchers found that a 10% cap would save Americans roughly $100 billion in interest annually. The American Bankers Association warned that such a cap "would only drive consumers toward less regulated, more costly alternatives." Further reading: How Trump's proposed cap on credit card rates could reshape consumer lending.

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Immediate retirement for freebie automation platform

Microsoft has abruptly pulled the plug on the venerable Microsoft Deployment Toolkit (MDT), sending any administrators still clinging to the platform scrambling for alternatives.…

AI firm promises HIPAA-compliant integrations as chatbot moves into hospital admin

Fresh from watching rival OpenAI stick its nose into patient records, Anthropic has decided now is the perfect moment to march Claude into US healthcare too, promising to fix medicine with yet more AI, APIs, and carefully-worded reassurances about privacy.…

Cloudflare CEO Matthew Prince has threatened to withdraw free cybersecurity services from Italy's Milano-Cortina Winter Olympics and potentially exit the country after Italy's telecommunications regulator fined the company approximately 14 million euros for failing to comply with anti-piracy blocking orders. The penalty equals 1% of Cloudflare's global annual revenue but exceeds twice what the company earned from Italy in 2024. Prince called Italy's Autorita per le Garanzie nelle Comunicazioni a "quasi-judicial body" administering a "scheme to censor the Internet" on behalf of "a shadowy cabal of European media elites." The fine stems from Cloudflare's refusal to comply with Italy's Piracy Shield law, which requires internet service providers and DNS operators to block sites within 30 minutes of receiving blocking requests from copyright holders. Prince said Cloudflare may discontinue free services for Italian users, remove servers from Italian cities and cancel plans to build an Italian office.

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Sick astronaut back on Earth by Thursday, nature of ailment remains undisclosed

NASA astronaut Mike Fincke has handed command of the ISS to Roscosmos cosmonaut Sergey Kud-Sverchkov as Fincke and the rest of Crew-11 are scheduled to head back to Earth on Wednesday.…

Streamer spend on content is set to top the $100 billion mark for the first time this year, according to an Ampere Analysis report. From a report: The landmark figure will be met as global streamers "remain the primary driver of growth in content investment," according to Ampere. Spend by the likes of Netflix, Disney+, Prime Video, HBO Max, Paramount+ and Apple TV will shoot up 6% this year, helping lead to a 2% increase in overall global content spend, Ampere forecast. The $101 billion figure, the first time streamer spend has crossed that major $100 Billion landmark, will represent around two-fifths of the overall figure.

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Yes, you can get rid of it – assuming nobody's looked at it in 28 days

Microsoft's latest Windows Insider release introduces a policy allowing admins to remove the Copilot app from managed devices. But there's a catch - actually, several.…

Website built around buying and selling stolen data has lost control of its own

BreachForums, the serially resurrected cybercrime marketplace, has tripped over itself after a data breach spilled details tied to about 324,000 user accounts.…